Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
EV9800000
CHEMICAL NAME :
Calcium
chloride
CAS REGISTRY NUMBER :
10043-52-4
LAST UPDATED :
199710
DATA ITEMS
CITED :
33
MOLECULAR FORMULA :
Ca-Cl2
MOLECULAR WEIGHT :
110.98
WISWESSER
LINE NOTATION :
CA G2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES
OBSERVED :
Human - woman
DOSE/DURATION :
20 mg/kg/1H-C
TOXIC EFFECTS :
Skin
and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic
- changes in calcium
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1
gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
264
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2630
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
161
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1940 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
210
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral
- convulsions or effect on seizure threshold Behavioral - changes in motor activity
(specific assay)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
823
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
274
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
274
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
249
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
249
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1384 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
472
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
274
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
150
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intraarterial
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
300
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
666
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2016
mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of
CNS Cardiac - pulse rate Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TCLo
- Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES
OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
43 mg/m3/4H/17W-I
TOXIC
EFFECTS :
Blood - change in clotting factors Blood - changes in serum composition (e.g.
TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood
or tissue levels - catalases
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
112 gm/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by
RTECS criteria Endocrine - thyroid tumors
TYPE OF TEST :
Unscheduled DNA
synthesis
MUTATION DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM
:
Rodent - rat Ascites tumor
DOSE/DURATION :
3500 mg/kg
REFERENCE :
GANNA2
Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher
information, see JJCREP. Volume(issue)/page/year: 54,155,1963 *** U.S. STANDARDS AND
REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC
Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC
20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND
SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational
Hazard Survey (1974) NOHS Hazard Code - 15720 No. of Facilities: 7996 (estimated) No. of
Industries: 87 No. of Occupations: 79 No. of Employees: 110691 (estimated) NOES - National
Occupational Exposure Survey (1983) NOES Hazard Code - 15720 No. of Facilities: 15168
(estimated) No. of Industries: 116 No. of Occupations: 113 No. of Employees: 354620
(estimated) No. of Female Employees: 117433 (estimated)
