Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
DE4550000
CHEMICAL NAME
:
1,2-Benzisothiazolin-3-one, 1,1-dioxide, sodium salt
CAS REGISTRY NUMBER
:
128-44-9
LAST UPDATED :
199806
DATA ITEMS CITED :
57
MOLECULAR FORMULA
:
C7-H4-N-O3-S.Na
MOLECULAR WEIGHT :
205.17
WISWESSER LINE NOTATION :
T56
BSWMVJ &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
14200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
7100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
17500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than
lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7
gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4 gm/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
756 gm/kg/36W-C
TOXIC EFFECTS
:
Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder -
other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE
OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
32400 mg/kg/54D-C
TOXIC EFFECTS
:
Immunological Including Allergic - decrease in humoral immune response
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
1092 gm/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic -
Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
176 mg/kg
TOXIC EFFECTS :
Tumorigenic -
neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors Tumorigenic - tumors at site
of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
112
gm/kg/8W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter,
Bladder - Kidney tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose
(other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
224 gm/kg/8W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by
RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors
TYPE
OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
1330 gm/kg/95W-C
TOXIC EFFECTS
:
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder -
tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2660
gm/kg/95W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS
criteria Kidney, Ureter, Bladder - tumors Kidney, Ureter, Bladder - changes in blood vessels
or in circulation of kidney
TYPE OF TEST :
TD - Toxic dose (other than
lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
1428 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal
tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Kidney, Ureter, Bladder
- changes in blood vessels or in circulation of kidney
TYPE OF TEST :
TD - Toxic dose
(other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
1190 gm/kg/85W-C
TOXIC EFFECTS :
Tumorigenic - equivocal
tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Kidney, Ureter,
Bladder - changes in blood vessels or in circulation of kidney
TYPE OF TEST :
TD -
Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
1827 gm/kg/87W-C
TOXIC EFFECTS :
Tumorigenic -
Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15
gm/kg
SEX/DURATION :
lactating female 15-21 day(s) post-birth
TOXIC EFFECTS
:
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
325 gm/kg
SEX/DURATION :
male 4 week(s) pre-mating female 4
week(s) pre-mating - 4 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on
Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
103 gm/kg
SEX/DURATION
:
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or
Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
multigenerations
TOXIC
EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
2
gm/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive -
Fertility - male fertility index (e.g. # males impregnating females per # males exposed to
fertile nonpregnant females)
TYPE OF TEST :
Sex chromosome loss and
nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST
:
Unscheduled DNA synthesis
TYPE OF TEST :
DNA damage
TYPE OF TEST
:
Cytogenetic analysis
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST
:
Dominant lethal test
TYPE OF TEST :
Sperm Morphology
MUTATION DATA
TYPE OF
TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION
:
1 gm/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261
34 Landskrona, Sweden) V.1- 1947- Volume(issue)/page/year: 70,271,1972 *** REVIEWS *** IARC
Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave.,
Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,111,1980 IARC Cancer Review:Group
2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave.,
Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,334,1987 TOXICOLOGY REVIEW AEHLAU
Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC
20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 TOXICOLOGY REVIEW EVHPAZ EHP,
Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents,
Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 25,173,1978 TOXICOLOGY REVIEW
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1-
1973- Volume(issue)/page/year: 24,253,1983 TOXICOLOGY REVIEW FAATDF Fundamental and Applied
Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - 80527 No. of Facilities: 2086 (estimated) No. of Industries: 17
No. of Occupations: 22 No. of Employees: 13433 (estimated) NOES - National Occupational
Exposure Survey (1983) NOES Hazard Code - X8578 No. of Facilities: 11 (estimated) No. of
Industries: 1 No. of Occupations: 5 No. of Employees: 1150 (estimated) No. of Female
Employees: 591 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard
Code - 80527 No. of Facilities: 1735 (estimated) No. of Industries: 18 No. of Occupations:
44 No. of Employees: 67252 (estimated) No. of Female Employees: 49525 (estimated)
FAQ
1.What is Sodium Saccharin?
Sodium Saccharin is an organic compound with no nutritional value for
humans. When consumed in large quantities, it affects the normal secretion of digestive
enzymes in the stomach and intestines, reduces the absorptive capacity of the small
intestine, and diminishes appetite. Many countries have restricted the use of sodium
saccharin in food processing. In the production and operation activities, a small number
of enterprises in order to one-sided pursuit of product sweetness, color or prolong the
shelf life of products, unauthorized and illegal overuse of sodium saccharin and other
food additives, posing a potential threat to human health.
Sodium saccharin is a synthetic sweetener commonly used in the food industry and has the
longest history of use, but it is also the most controversial synthetic sweetener.
Sodium saccharin is 300 to 500 times sweeter than sucrose.
2.How is Sodium Saccharin produced?
Typically, saccharin sodium is produced mainly by the toluene method and
the phthalic anhydride method. Among them, in the process of producing saccharin sodium
by toluene method, o-toluenesulfonamide, an intermediate product, is generally
generated, and o-toluenesulfonamide often generates insoluble saccharin after oxidation
and acid precipitation. In the actual production process, due to the incomplete
oxidation, the unreacted o-toluenesulfonamide can not be completely separated, and
o-toluenesulfonamide is a carcinogen, in this case, the national industrial policy
further restricts the development of saccharin sodium industry. For this reason, the
state of sodium saccharin products for the production of fixed-point, limited production
and marketing control, for the annual production plan, enterprises need to be approved,
in the use of sodium saccharin products also has a strict management.
3.How is Sodium Saccharin stored and distributed?
1. Food grade should be transported and stored according to food hygiene
requirements. Avoid mixing and transporting, and load and unload lightly when handling
to prevent damage to the package.
2. Precautions for safe operation: In places where dust is generated, provide suitable
exhaust equipment. General fire protection measures.
3. Storage conditions:Keep sealed and keep away from light Temperature conditions:Room
temperature
4. Moisture-proofing:To avoid the bag from breaking, to avoid its moisture and rain, so
as to ensure that its properties will not change.
To avoid unnecessary losses.
5. Anti-temperature: when under the influence of high temperature, performance,
properties will be more or less affected, therefore, in the storage must avoid high
temperature.
6. Fire prevention: When storing, pay special attention to fire prevention.
4.What is Sodium Saccharin used for?
It is the earliest application of synthetic non-nutritive sweetener,
soluble in water, the sweetness in dilute solution is 200~500 times of sucrose, with a
bitter taste when the concentration is large, and when it is heated under acidic
conditions, the sweetness disappears and bitter o-aminosulfonylbenzoic acid can be
formed. Because of its low calorie, not absorbed by the body, can be automatically
excreted with urine and feces and other characteristics of obesity, high blood
cholesterol, diabetes and dental caries and other patients used as sugar substitutes.
General cold drinks, beverages, jellies, popsicles, sauces, preserves, pastries, cold
fruits, meringue and so on. Applied to the food industry and diabetic patients for
sweetened diet, commonly used synthetic sweeteners.
