Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
UQ0840000
CHEMICAL NAME :
4H-Pyran-4-one,
2-ethyl-3-hydroxy-
CAS REGISTRY NUMBER :
4940-11-8
BEILSTEIN REFERENCE NO.
:
1618110
LAST UPDATED :
199712
DATA ITEMS CITED :
9
MOLECULAR FORMULA
:
C7-H8-O3
MOLECULAR WEIGHT :
140.15
HEALTH HAZARD DATA
ACUTE TOXICITY
DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1150 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
780 mg/kg
TOXIC EFFECTS :
Details
of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
910 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED
:
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird -
chicken
DOSE/DURATION :
1270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
90 gm/kg/90D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules
(including acute renal failure, acute tubular necrosis)
MUTATION DATA
TYPE OF TEST
:
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella
typhimurium
DOSE/DURATION :
2 mg/plate
REFERENCE :
MUREAV Mutation Research.
(Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
Volume(issue)/page/year: 67,367,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey
(1983) NOES Hazard Code - T2072 No. of Facilities: 193 (estimated) No. of Industries: 6 No.
of Occupations: 8 No. of Employees: 4632 (estimated) No. of Female Employees: 1504
(estimated)
