Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
RG5075000
CHEMICAL NAME :
2,6-Octadienal,
3,7-dimethyl-
CAS REGISTRY NUMBER :
5392-40-5
BEILSTEIN REFERENCE NO.
:
1721871
LAST UPDATED :
199801
DATA ITEMS CITED :
30
MOLECULAR FORMULA
:
C10-H16-O
MOLECULAR WEIGHT :
152.26
WISWESSER LINE NOTATION
:
VH1UY1&3Y1&U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST
:
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES
OBSERVED :
Human
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE
:
Administration onto the skin
SPECIES OBSERVED :
Human - man
TYPE OF TEST
:
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES
OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE
:
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST
:
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES
OBSERVED :
Mammal - pig
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE
:
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
TYPE OF
TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the
skin
SPECIES OBSERVED :
Rodent - guinea pig
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
4960 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general
depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 gm/kg
TOXIC
EFFECTS :
Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES
OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2250 mg/kg
TOXIC EFFECTS :
Details
of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
24 gm/kg/10D-I
TOXIC EFFECTS :
Liver - changes in liver
weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels -
hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Effect on
specific coenzyme - CoA
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14952
mg/kg/14D-I
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1250 mg/kg
SEX/DURATION :
female 6-15
day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus -
fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 mg/kg
SEX/DURATION
:
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility -
female fertility index (e.g. # females pregnant per # sperm positive females; # females
pregnant per # females mated) Reproductive - Specific Developmental Abnormalities - other
developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE
OF EXPOSURE :
Oral
DOSE :
10 gm/kg
SEX/DURATION :
female 6-15 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants
per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or
Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
DOSE :
10 gm/kg
SEX/DURATION :
female 6-15 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
musculoskeletal system Reproductive - Effects on Newborn - sex ratio
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the
skin
DOSE :
28 gm/kg
SEX/DURATION :
female 60 day(s) pre-mating
TOXIC EFFECTS
:
Reproductive - Maternal Effects - oogenesis Reproductive - Fertility - pre-implantation
mortality (e.g. reduction in number of implants per female; total number of implants per
corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
46
gm/kg
SEX/DURATION :
female 14 week(s) pre-mating
TOXIC EFFECTS :
Reproductive -
Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto
the skin
DOSE :
46 gm/kg
SEX/DURATION :
female 14 week(s) pre-mating
TOXIC
EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive -
Fertility - other measures of fertility Reproductive - Effects on Newborn - viability index
(e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
27600
mg/kg
SEX/DURATION :
female 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive -
Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1800
mg/kg
SEX/DURATION :
female 22 week(s) pre-mating
TOXIC EFFECTS :
Reproductive -
Maternal Effects - oogenesis Reproductive - Fertility - pre-implantation mortality (e.g.
reduction in number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants
per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1800 mg/kg
SEX/DURATION
:
female 6 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects -
ovaries, fallopian tubes Reproductive - Effects on Newborn - live birth index (measured
after birth)
MUTATION DATA
TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria -
Bacillus subtilis
DOSE/DURATION :
2222 ug/disc
REFERENCE :
OIGZDE Osaka-shi
Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o
Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975-
Volume(issue)/page/year: 34,267,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - 83184 No. of Facilities: 353 (estimated) No. of Industries: 5 No.
of Occupations: 33 No. of Employees: 68051 (estimated) NOES - National Occupational Exposure
Survey (1983) NOES Hazard Code - 83184 No. of Facilities: 12505 (estimated) No. of
Industries: 98 No. of Occupations: 84 No. of Employees: 200484 (estimated) No. of Female
Employees: 83180 (estimated)
