Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
WG2932500
CHEMICAL NAME :
Sorbitan,
monooleate polyoxyethylene deriv.
CAS REGISTRY NUMBER :
9005-65-6
LAST UPDATED
:
199710
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard
Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED
:
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
34500
uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6804
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1790
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 gm/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7600
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4500
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
500
mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting
reflex) Cardiac - other changes
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal -
cat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time
(including change in righting reflex) Cardiac - other changes
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal
- species unspecified
DOSE/DURATION :
25 gm/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal -
species unspecified
DOSE/DURATION :
5800 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
42 gm/kg/2W-C
TOXIC EFFECTS :
Nutritional and Gross
Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
2163 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal
tumorigenic agent by RTECS criteria Endocrine - adrenal cortex tumors
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg/27W-I
TOXIC EFFECTS
:
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at
site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
DOSE :
635 gm/kg
SEX/DURATION :
multigenerations
TOXIC
EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per
# born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive
at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1270 gm/kg
SEX/DURATION :
female 84
day(s) pre-mating - 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on
Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE
:
80 uL/kg
SEX/DURATION :
lactating female 4 day(s) post-birth
TOXIC EFFECTS
:
Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal
Effects - menstrual cycle changes or disorders Reproductive - Effects on Newborn -
physical
MUTATION DATA
TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent -
mouse Cells - not otherwise specified
DOSE/DURATION :
20 ppm
REFERENCE :
ENPBBC
Environmental Physiology and Biochemistry. (Copenhagen, Denmark) V.2-5, 1972-75.
Discontinued. Volume(issue)/page/year: 5,84,1975 *** REVIEWS *** TOXICOLOGY REVIEW ARTODN
Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep.
Ger.) V.32- 1974- Volume(issue)/page/year: 32,245,1974 *** U.S. STANDARDS AND REGULATIONS
*** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal
Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1-
1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE
DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard
Survey (1974) NOHS Hazard Code - 80605 No. of Facilities: 1388 (estimated) No. of
Industries: 18 No. of Occupations: 32 No. of Employees: 24861 (estimated) NOES - National
Occupational Exposure Survey (1983) NOES Hazard Code - X8582 No. of Facilities: 6365
(estimated) No. of Industries: 38 No. of Occupations: 70 No. of Employees: 162120
(estimated) No. of Female Employees: 112349 (estimated)
