Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
TR7400000
CHEMICAL NAME :
Polysorbate
20
CAS REGISTRY NUMBER :
9005-64-5
LAST UPDATED :
199710
DATA ITEMS CITED
:
21
MOLECULAR FORMULA :
C58-H114-O26
MOLECULAR WEIGHT :
1227.72
HEALTH
HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize test
ROUTE OF
EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
REFERENCE
:
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and
P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977 **
ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
36700
uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
3850 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
ARZNAD
Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960
Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1581,1976
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
770 mg/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD
Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960
Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1581,1976
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
>33 gm/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
ARZNAD
Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960
Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1581,1976
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2640
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year:
26,1581,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1420
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal
Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year:
2,316,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
18 mL/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE
:
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see
JFDSAZ. Volume(issue)/page/year: 21,348,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE
OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
832 gm/kg/59D-C
TOXIC EFFECTS
:
Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
REFERENCE
:
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 34,249,1951
TYPE OF TEST :
TDLo
- Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- rat
DOSE/DURATION :
931 gm/kg/70D-C
TOXIC EFFECTS :
Gastrointestinal -
hypermotility, diarrhea Liver - fatty liver degeneration Liver - other changes
REFERENCE
:
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 34,249,1951
TYPE OF TEST :
TDLo
- Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- rat
DOSE/DURATION :
2756 gm/kg/21W-C
TOXIC EFFECTS :
Gastrointestinal -
hypermotility, diarrhea Kidney, Ureter, Bladder - other changes Blood - other
changes
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For
publisher information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
33250 gm/kg/95W-C
TOXIC EFFECTS :
Blood -
pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC)
count
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1
E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,320,1965
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - hamster
DOSE/DURATION :
3276 gm/kg/39W-C
TOXIC EFFECTS
:
Gastrointestinal - other changes Liver - other changes Blood - changes in
spleen
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For
publisher information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956 ** REPRODUCTIVE DATA
**
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
1 gm/kg
SEX/DURATION :
female 9 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
musculoskeletal system
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C:
Biosciences. (Verlag der Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen,
Fed. Rep. Ger.) V.29- 1974- Volume(issue)/page/year: 36,904,1981
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
2500
mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed
implants per total number of implants)
REFERENCE :
ZNCBDA Zeitschrift fuer
Naturforschung, Section C: Biosciences. (Verlag der Zeitschrift fuer Naturforschung,
Postfach 2645, D-7400 Tuebingen, Fed. Rep. Ger.) V.29- 1974- Volume(issue)/page/year:
36,904,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
1 gm/kg
SEX/DURATION :
female 9 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other
developmental abnormalities
REFERENCE :
TJADAB Teratology, The International Journal
of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 26(3),19A,1982 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA
1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S.
Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey
(1983) NOES Hazard Code - X6874 No. of Facilities: 5475 (estimated) No. of Industries: 22
No. of Occupations: 48 No. of Employees: 161625 (estimated) No. of Female Employees: 125776
(estimated)
