Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
UQ6400000
CHEMICAL NAME
:
Pyrazole-3-carboxylic acid, 5-hydroxy-1-(p-sulfophenyl)-4-(p-sulfophenyl)azo-,
trisodium salt
CAS REGISTRY NUMBER :
1934-21-0
LAST UPDATED :
199710
DATA
ITEMS CITED :
23
MOLECULAR FORMULA :
C16-H9-N4-O9-S2.3Na
MOLECULAR WEIGHT
:
534.38
WISWESSER LINE NOTATION :
T5NNJ AR DSWO& CVO DNUNR DSWO& EQ &-NA-
3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION
:
14 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
Musculoskeletal - changes in teeth and supporting structures
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
12750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than
lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
476
mg/kg/28D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
18500
mg/kg
SEX/DURATION :
female 7-22 day(s) after conception lactating female 21 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood
and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn -
growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn -
behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
1280 mg/kg
SEX/DURATION :
female 7-14 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation
index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
20 gm/kg
SEX/DURATION
:
female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on
Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
Specific locus
test
MUTATION DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Mammal -
species unspecified Fibroblast
DOSE/DURATION :
5 mg/L
REFERENCE :
FCTOD7 Food
and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY
10523) V.20- 1982- Volume(issue)/page/year: 20,461,1982 *** REVIEWS *** TOXICOLOGY REVIEW
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
Volume(issue)/page/year: 9,198,1975 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S.
Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - M2148 No. of Facilities: 2666 (estimated) No. of Industries: 32
No. of Occupations: 45 No. of Employees: 47875 (estimated) NOES - National Occupational
Exposure Survey (1983) NOES Hazard Code - M2148 No. of Facilities: 15429 (estimated) No. of
Industries: 95 No. of Occupations: 99 No. of Employees: 318163 (estimated) No. of Female
Employees: 157622 (estimated)
