Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
QK2450000
CHEMICAL NAME
:
2-Naphthalenesulfonic acid, 6-hydroxy-5-((p-sulfophenyl)azo)-, disodium salt
CAS
REGISTRY NUMBER :
2783-94-0
LAST UPDATED :
199707
DATA ITEMS CITED
:
19
MOLECULAR FORMULA :
C16-H10-N2-O7-S2.2Na
MOLECULAR WEIGHT
:
452.38
WISWESSER LINE NOTATION :
L66J BNUNR DSWQ& CQ HSWQ &-NA- 2
HEALTH
HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
>10 gm/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3800
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- mouse
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Gastrointestinal -
hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
4600 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure
threshold Behavioral - coma Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
243 gm/kg/96D-C
TOXIC EFFECTS
:
Gastrointestinal - other changes Related to Chronic Data - changes in testicular
weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
476
mg/kg/28D-C
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
MUTATION
DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster
Lung
DOSE/DURATION :
2 gm/L
REFERENCE :
GMCRDC Gann Monograph on Cancer
Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** IARC Cancer Review:Animal Inadequate
Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man.
(WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
Volume(issue)/page/year: 8,257,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC
Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year:
8,257,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15,
1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974 ***
NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY
DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2135 No. of
Facilities: 2510 (estimated) No. of Industries: 14 No. of Occupations: 21 No. of Employees:
17624 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code -
M2135 No. of Facilities: 11207 (estimated) No. of Industries: 67 No. of Occupations: 62 No.
of Employees: 195835 (estimated) No. of Female Employees: 103566 (estimated)
