Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
VZ2000000
CAS REGISTRY NUMBER
:
7631-90-5
LAST UPDATED :
199712
DATA ITEMS CITED :
52
MOLECULAR FORMULA
:
H-O3-S.Na
MOLECULAR WEIGHT :
104.06
WISWESSER LINE NOTATION :
NA
S-O2-Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
475 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time
(including change in righting reflex) Behavioral - convulsions or effect on seizure
threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
115
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other
changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
675
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory
depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other
changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
244
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory
depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
300
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory
depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
65
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other
changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
779
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
487
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
95
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other
changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4381
mg/kg/21D-I
TOXIC EFFECTS :
Liver - other changes Blood - changes in serum composition
(e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in
blood or tissue levels - other oxidoreductases
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
450 mg/kg/3W-I
TOXIC EFFECTS :
Vascular - thrombosis
distant from injection site Skin and Appendages - dermatitis, other (after systemic
exposure)
MUTATION DATA
TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM
:
Rodent - hamster Embryo
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ.
Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 11,1869,1990 *** REVIEWS *** ACGIH TLV-Not classifiable as a human
carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs)
booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH),
Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 5 mg/m3 DTLVS* The
Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Inadequate Evidence IMEMDT
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO
Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
Volume(issue)/page/year: 54,131,1992 IARC Cancer Review:Animal Inadequate Evidence IMEMDT
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO
Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
Volume(issue)/page/year: 54,131,1992 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on
the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 54,131,1992 *** U.S.
STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR
RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 ***
OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg/m3
JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FRANCE:TWA 5 mg/m3 JAN 1993 OEL-THE
NETHERLANDS:TWA 5 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA
5 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW
ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE
DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO SODIUM BISULFITE-air:10H TWA
5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS
#92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard
Survey (1974) NOHS Hazard Code - M1055 No. of Facilities: 23628 (estimated) No. of
Industries: 147 No. of Occupations: 92 No. of Employees: 133191 (estimated) NOES - National
Occupational Exposure Survey (1983) NOES Hazard Code - M1055 No. of Facilities: 22338
(estimated) No. of Industries: 144 No. of Occupations: 110 No. of Employees: 296327
(estimated) No. of Female Employees: 119535 (estimated)
