Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
TT3750000
CAS REGISTRY NUMBER
:
7758-09-0
LAST UPDATED :
199701
DATA ITEMS CITED :
16
MOLECULAR FORMULA
:
N-O2.K
MOLECULAR WEIGHT :
85.11
WISWESSER LINE NOTATION
:
.KA..N-O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Human
DOSE/DURATION :
1428 ug/kg
TOXIC EFFECTS :
Sense Organs and Special
Senses (Ear) - tinnitus Cardiac - pulse rate increase, without fall in BP Vascular - BP
lowering not characterized in autonomic section
TYPE OF TEST :
LC50 - Lethal
concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
85 gm/m3/2H
TOXIC EFFECTS :
Behavioral -
sleep Behavioral - excitement Behavioral - muscle contraction or spasticity
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rabbit
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
18 gm/kg/13W-C
TOXIC EFFECTS :
Blood - pigmented or
nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin Nutritional and Gross
Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
30 gm/kg
SEX/DURATION
:
male 60 day(s) pre-mating female 60 day(s) pre-mating
TOXIC EFFECTS
:
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm
positive females; # females pregnant per # females mated)
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
137 gm/kg
SEX/DURATION
:
female 18 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn -
stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
201 gm/kg
SEX/DURATION :
female 19 week(s) pre-mating
TOXIC
EFFECTS :
Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus -
other effects to embryo
MUTATION DATA
TYPE OF TEST :
DNA inhibition
TEST SYSTEM
:
Microorganism - not otherwise specified
DOSE/DURATION :
20 mmol/L
REFERENCE
:
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1959- Volume(issue)/page/year: 5,442,1962 *** NIOSH STANDARDS DEVELOPMENT AND
SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational
Hazard Survey (1974) NOHS Hazard Code - 83413 No. of Facilities: 205 (estimated) No. of
Industries: 11 No. of Occupations: 7 No. of Employees: 1353 (estimated) NOES - National
Occupational Exposure Survey (1983) NOES Hazard Code - 83413 No. of Facilities: 788
(estimated) No. of Industries: 22 No. of Occupations: 34 No. of Employees: 27303 (estimated)
No. of Female Employees: 2845 (estimated)
