Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
QJ6530000
CHEMICAL NAME
:
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-, trisodium
salt
CAS REGISTRY NUMBER :
2611-82-7
LAST UPDATED :
199709
DATA ITEMS CITED
:
16
MOLECULAR FORMULA :
C20-H14-N2-O10-S3.3Na
MOLECULAR WEIGHT
:
607.51
WISWESSER LINE NOTATION :
L66J CO HSWO JSWO BNUN- BL66J ESWO &-NA-
4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general
depressed activity) Behavioral - convulsions or effect on seizure threshold Kidney, Ureter,
Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
600
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral
- convulsions or effect on seizure threshold Behavioral - coma
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral
- convulsions or effect on seizure threshold Behavioral - coma
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
143 gm/kg/90D-C
TOXIC EFFECTS :
Blood - pigmented or
nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or
tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
30 gm/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules
(including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other
changes in urine composition
TYPE OF TEST :
TCLo - Lowest published toxic
concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
48 mg/m3/17W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration
- structural or functional change in trachea or bronchi Liver - liver function tests
impaired Blood - other changes
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
428 gm/kg/64W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by
RTECS criteria Liver - tumors
MUTATION DATA
TYPE OF TEST :
Cytogenetic
analysis
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
1
gm/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY
DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4494 No. of
Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 138
(estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4494 No.
of Facilities: 1035 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees:
8379 (estimated) No. of Female Employees: 2006 (estimated)
