Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
DU3000000
CHEMICAL NAME :
(delta(sup
2,2')-Biindoline)-5,5'-disulfonic acid, 3,3'-dioxo-, disodium salt
CAS REGISTRY NUMBER
:
860-22-0
LAST UPDATED :
199709
DATA ITEMS CITED :
16
MOLECULAR FORMULA
:
C16-H8-N2-O8-S2.2Na
MOLECULAR WEIGHT :
466.36
WISWESSER LINE NOTATION :
T56
BMYVJ GSWO CU- CT56 BMYVJ GSWO &-NA- 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE
OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of
toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent
- rat
DOSE/DURATION :
93 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than
lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
405
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9
gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic -
tumors at site of application
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST
:
Cytogenetic analysis
TYPE OF TEST :
Sister chromatid exchange
MUTATION
DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster
Ovary
DOSE/DURATION :
20 umol/L/5H (Continuous)
REFERENCE :
ENMUDM Environmental
Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84752 No. of Facilities: 314 (estimated) No. of Industries: 5 No. of
Occupations: 6 No. of Employees: 1736 (estimated) NOES - National Occupational Exposure
Survey (1983) NOES Hazard Code - 84752 No. of Facilities: 393 (estimated) No. of Industries:
7 No. of Occupations: 28 No. of Employees: 9691 (estimated) No. of Female Employees: 3035
(estimated)
