Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
LQ1040000
CHEMICAL NAME :
Formamide,
1,1'-azobis-
CAS REGISTRY NUMBER :
123-77-3
LAST UPDATED :
199710
DATA ITEMS
CITED :
16
MOLECULAR FORMULA :
C2-H4-N4-O2
MOLECULAR WEIGHT
:
116.10
WISWESSER LINE NOTATION :
ZVNUNVZ
HEALTH HAZARD DATA
ACUTE TOXICITY
DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>6400 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto
the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
440
mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
42 gm/kg/10D-C
TOXIC EFFECTS :
Endocrine -
evidence of thyroid hypofunction Endocrine - changes in thyroid weight
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
233 gm/kg/4W-C
TOXIC EFFECTS :
Endocrine -
evidence of thyroid hypofunction
TYPE OF TEST :
TCLo - Lowest published toxic
concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
207 mg/m3/6H/2W-I
TOXIC EFFECTS :
Liver - changes in liver
weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF
TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
:
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
204
mg/m3/6H/13W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP,
bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
252 mg/kg/1W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria Related to
Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic
concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
217 mg/m3/6H/2W-I
TOXIC EFFECTS :
Liver - changes in liver
weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF
TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
:
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
204
mg/m3/6H/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Nutritional and Gross
Metabolic - weight loss or decreased weight gain
MUTATION DATA
TYPE OF TEST
:
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella
typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
ENMUDM Environmental
Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
Volume(issue)/page/year: 8(Suppl 7),1,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE
DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard
Survey (1974) NOHS Hazard Code - 81713 No. of Facilities: 1753 (estimated) No. of
Industries: 32 No. of Occupations: 60 No. of Employees: 43147 (estimated) NOES - National
Occupational Exposure Survey (1983) NOES Hazard Code - 81713 No. of Facilities: 1210
(estimated) No. of Industries: 18 No. of Occupations: 29 No. of Employees: 42296 (estimated)
No. of Female Employees: 17091 (estimated)
