Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
QJ6550000
CHEMICAL NAME
:
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthyl)azo)-, trisodium
salt
CAS REGISTRY NUMBER :
915-67-3
LAST UPDATED :
199709
DATA ITEMS CITED
:
36
MOLECULAR FORMULA :
C20-H11-N2-O10-S3.3Na
MOLECULAR WEIGHT
:
604.48
WISWESSER LINE NOTATION :
L66J BSWQ ENUN- BL66J CQ DSWQ HSWQ &-NA-
3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general
depressed activity)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
96550
ug/kg/28D-C
TOXIC EFFECTS :
Liver - changes in liver weight
TYPE OF TEST :
TDLo
- Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- rat
DOSE/DURATION :
680 gm/kg/14W-I
TOXIC EFFECTS :
Tumorigenic - equivocal
tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - lymphoma, including
Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200
gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood -
lymphoma, including Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than
lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
1643 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal
tumorigenic agent by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
548
mg/kg
SEX/DURATION :
female 52 week(s) pre-mating
TOXIC EFFECTS :
Reproductive -
Maternal Effects - menstrual cycle changes or disorders
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
547 mg/kg
SEX/DURATION
:
multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - female fertility
index (e.g. # females pregnant per # sperm positive females; # females pregnant per #
females mated) Reproductive - Effects on Newborn - live birth index (measured after
birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
33 mg/kg
SEX/DURATION :
female 1-22 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality
(e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility -
litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
65
mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on
Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific
Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
296 mg/kg
SEX/DURATION
:
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability
index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth
statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
548 mg/kg
SEX/DURATION :
male 52
week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis
(incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3528
ug/kg
SEX/DURATION :
male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE
:
4550 uL/kg
SEX/DURATION :
male 4 week(s) pre-mating female 4 week(s) pre-mating -
2 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other
effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
DOSE :
4900 uL/kg
SEX/DURATION :
male 4 week(s) pre-mating
female 4 week(s) pre-mating - 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive -
Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
12
mL/kg
SEX/DURATION :
male 4 week(s) pre-mating female 4 week(s) pre-mating - 4 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intraperitoneal
DOSE :
250 mg/kg
SEX/DURATION :
male 1 day(s)
pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. #
males impregnating females per # males exposed to fertile nonpregnant females) Reproductive
- Fertility - pre-implantation mortality (e.g. reduction in number of implants per female;
total number of implants per corpora lutea)
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
16500 ug/kg
SEX/DURATION
:
female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility -
post-implantation mortality (e.g. dead and/or resorbed implants per total number of
implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intravenous
DOSE :
100 mg/kg
SEX/DURATION :
female 8 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
musculoskeletal system
MUTATION DATA
TYPE OF TEST :
Cytogenetic analysis
TEST
SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
2 gm/L
REFERENCE :
GMCRDC Gann
Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.
11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** IARC Cancer Review:Animal
Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1-
1972- Volume(issue)/page/year: 8,41,1975 IARC Cancer Review:Human No Adequate Data IMEMDT
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO
Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
Volume(issue)/page/year: 8,41,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs,
Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology.
(Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
Volume(issue)/page/year: 14,127,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - M2137 No. of Facilities: 1931 (estimated) No. of Industries: 9 No.
of Occupations: 12 No. of Employees: 13075 (estimated) NOES - National Occupational Exposure
Survey (1983) NOES Hazard Code - M2137 No. of Facilities: 2272 (estimated) No. of
Industries: 12 No. of Occupations: 22 No. of Employees: 13792 (estimated) No. of Female
Employees: 5645 (estimated)
