Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
AK3675000
CHEMICAL NAME :
Acetin,
tri-
CAS REGISTRY NUMBER :
102-76-1
BEILSTEIN REFERENCE NO. :
1792353
LAST
UPDATED :
199701
DATA ITEMS CITED :
15
MOLECULAR FORMULA
:
C9-H14-O6
MOLECULAR WEIGHT :
218.23
WISWESSER LINE NOTATION
:
1VO1YOV1&1OV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST
:
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES
OBSERVED :
Rodent - rabbit
REFERENCE :
JPETAB Journal of Pharmacology and
Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
V.1- 1909/10- Volume(issue)/page/year: 82,377,1944 ** ACUTE TOXICITY DATA **
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
AMIHAB AMA Archives of
Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
Volume(issue)/page/year: 21,28,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
2100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics
Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
Volume(issue)/page/year: 16,879,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
2800 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general
depressed activity) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
PSEBAA
Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1
E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 46,26,1941
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS
:
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
Behavioral - altered sleep time (including change in righting reflex) Behavioral -
stiffness
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies
for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year:
22,368,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400
mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or
without sensory change Behavioral - altered sleep time (including change in righting reflex)
Behavioral - stiffness
REFERENCE :
FEPRA7 Federation Proceedings, Federation of
American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 22,368,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
2300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence
(general depressed activity) Lungs, Thorax, or Respiration - dyspnea
REFERENCE
:
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year:
46,26,1941
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - respiratory depression
REFERENCE :
APSCAX Acta Physiologica
Scandinavica. (Karolinska Institutet, S-10401 Stockholm, Sweden) V.1- 1940-
Volume(issue)/page/year: 40,338,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal -
dog
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics
Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
Volume(issue)/page/year: 16,879,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics
Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
Volume(issue)/page/year: 16,879,1978
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - guinea
pig
DOSE/DURATION :
1740 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration -
dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 76,189,1942
TYPE OF TEST :
LDLo - Lowest published lethal
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Amphibian -
frog
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics
Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
Volume(issue)/page/year: 16,879,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - M1910 No. of Facilities: 832 (estimated) No. of Industries: 17 No.
of Occupations: 25 No. of Employees: 11313 (estimated) NOES - National Occupational Exposure
Survey (1983) NOES Hazard Code - M1910 No. of Facilities: 713 (estimated) No. of Industries:
13 No. of Occupations: 21 No. of Employees: 18436 (estimated) No. of Female Employees: 4103
(estimated)
