Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
WI2800000
CHEMICAL NAME :
Stearic
acid
CAS REGISTRY NUMBER :
57-11-4
BEILSTEIN REFERENCE NO. :
0608585
LAST
UPDATED :
199710
DATA ITEMS CITED :
16
MOLECULAR FORMULA
:
C18-H36-O2
MOLECULAR WEIGHT :
284.54
WISWESSER LINE NOTATION
:
QV17
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize
test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED
:
Human
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference,
1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
Volume(issue)/page/year: -,127,1977
TYPE OF TEST :
Standard Draize test
ROUTE OF
EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent -
rabbit
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For publisher information, see FCTOD7. Volume(issue)/page/year: 17,383,1979 ** ACUTE
TOXICITY DATA **
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4640
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann
Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
Volume(issue)/page/year: 6(3),321,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
21500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or
effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE
:
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For
publisher information, see PHTOEH Volume(issue)/page/year: 18,141,1961
TYPE OF TEST
:
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Behavioral
- convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other
changes
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
18,141,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION
:
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19,
1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,383,1979 **
OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
313 gm/kg/30W-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE
:
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651
Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year:
14,196,1995 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal
tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
REFERENCE
:
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke,
Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 17,127,1963 *** REVIEWS ***
TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH
STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 69740 No. of
Facilities: 31794 (estimated) No. of Industries: 220 No. of Occupations: 159 No. of
Employees: 541742 (estimated) NOES - National Occupational Exposure Survey (1983) NOES
Hazard Code - X7032 No. of Facilities: 136 (estimated) No. of Industries: 3 No. of
Occupations: 11 No. of Employees: 9034 (estimated) No. of Female Employees: 7670 (estimated)
NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 69740 No. of
Facilities: 34970 (estimated) No. of Industries: 239 No. of Occupations: 165 No. of
Employees: 1123118 (estimated) No. of Female Employees: 568888 (estimated)
