Common Name	Cineole
CAS Number	470-82-6
Molecular Weight	154.249
Density	0.9±0.1 g/cm3
Boiling Point	174.0±8.0 °C at 760 mmHg
Molecular Formula	C10H18O
Melting Point	1.5ºC
MSDS	Chinese USA
Flash Point	50.9±15.3 °C
Symbol	GHS02
Signal Word	Warning

Density	0.9±0.1 g/cm3
Boiling Point	174.0±8.0 °C at 760 mmHg
Melting Point	1.5ºC
Molecular Formula	C10H18O
Molecular Weight	154.249
Flash Point	50.9±15.3 °C
Exact Mass	154.135757
PSA	9.23000
LogP	2.82
Vapour Pressure	1.6±0.3 mmHg at 25°C
Index of Refraction	1.461
Stability	Stable. Flammable. Incompatible with acids, bases, strong oxidizing agents.

CHEMICAL IDENTIFICATION
RTECS NUMBER :
OS9275000
CHEMICAL NAME :
p-Menthane, 1,8-epoxy-
CAS REGISTRY NUMBER :
470-82-6
LAST UPDATED :
199710
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C10-H18-O
MOLECULAR WEIGHT :
154.28
WISWESSER LINE NOTATION :
T66 A B AOTJ B1 B1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2480 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1070 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2 gm/kg
SEX/DURATION :
female 19-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
MUTATION DATA
TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
200 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** TOXICOLOGY REVIEW DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(4),10,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 19540 No. of Facilities: 1103 (estimated) No. of Industries: 11 No. of Occupations: 23 No. of Employees: 5213 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 19540 No. of Facilities: 4397 (estimated) No. of Industries: 48 No. of Occupations: 57 No. of Employees: 83399 (estimated) No. of Female Employees: 20158 (estimated)

Symbol	GHS02
Signal Word	Warning
Hazard Statements	H226
Precautionary Statements	P210-P370 + P378
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R10;R37/38;R41
Safety Phrases	S26-S39
RIDADR	UN 1993
WGK Germany	2
RTECS	OS9275000
Packaging Group	III
Hazard Class	3.0

N/A

1.What is Eucalyptol?

1. Used and stored according to specifications, no decomposition will occur, avoid contact with oxides. 2. Chemical properties: It is an extremely stable compound, does not decompose by distillation at atmospheric pressure, and does not act with reducing agents. It reacts with hydrogen bromide to form adduct C8H18O-HBr (m.p. 56~57℃). When oxidized with potassium permanganate, it produces eucalyptus brain acid (m.p. 204~206°C). Addition products can also be generated with phenols and phosphoric acid. 3. Exists in baking tobacco, white ribbed tobacco, and spice tobacco. 4. Naturally occurring in eucalyptus oil, rosemary oil, camphor oil, bay leaf oil, etc. 5. Water solubility: practically insoluble; water solubility: 3.5 g/l 21 °C; miscible: chloroform, alcohol, aether

2.How is Eucalyptol produced?

Eucalyptus brain is widely found in natural aromatic oils and is the main component of eucalyptus oil. Eucalyptus brain can be produced from aromatic oil. For example, eucalyptus oil can be fractionally distilled, and the 175-180℃ fraction can be collected and slightly refined. If it is necessary to manufacture products with higher purity, the eucalyptus brain obtained from the fractionation of aromatic oil can be cooled and dried by passing it through HCI. The hydrochloric acid and eucalyptus crystals are separated, the crystals are decomposed with hot water, and then pure eucalyptus brain is obtained by distillation. Synthesis method is to convert terpenes into acid, and then dehydration and obtained.

3.How is Eucalyptol stored and distributed?

Store under dry inert gas, keep container tightly closed, store in a cool, dry place Packed in galvanized iron drums. Store in a cool, ventilated place. The storage should be dedicated and not mixed with other items. Pay attention to fire prevention. Polymerization inhibitor should be added before storage and transportation. Before transportation, check whether the packing container is complete and sealed, and make sure the container is not leaking, collapsing, falling or damaged during transportation. Strictly prohibit mixing and transporting with oxidizing agents, acids, alkalis, edible chemicals and so on. The transport vehicle and ship must be thoroughly cleaned and sterilized, otherwise it is not allowed to ship other items. When transported by ship, the fitting position should be far away from bedrooms, kitchens, and isolated from the cabin, power supply, fire source and other parts. Road transportation should follow the prescribed route.

4.What is Eucalyptol used for?

Pharmaceuticals: Eucalyptol has antibacterial, anti-inflammatory, analgesic and other pharmacological effects, and is commonly used in pharmaceutical formulations as a topical disinfectant, analgesic and anti-inflammatory agent. It can be used to treat skin infections, eczema, burns, muscle pain and other diseases. Oral Care: Eucalyptol has antiseptic properties and is commonly used in oral care products such as toothpastes, mouthwashes and oral sprays. It can help prevent oral infections and bad breath, and soothe oral discomfort. Eucalyptus oil has the effect of activating blood circulation and removing blood stasis, regulating qi and relieving pain, and can be used to treat bruises, pain in the stomach and abdomen, vomiting blood, hemoptysis, blood in the stool and other symptoms.