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ethyl vanillin
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Basic
Common Name Ethyl vanillin
CAS Number 121-32-4
Molecular Weight 166.174
Density 1.2±0.1 g/cm3
Boiling Point 295.1±20.0 °C at 760 mmHg
Molecular Formula C9H10O3
Melting Point 76 °C
MSDS Chinese USA
Flash Point 119.0±15.3 °C
Symbol GHS07
Signal Word Warning
Physical Chemistry
Density 1.2±0.1 g/cm3
Boiling Point 295.1±20.0 °C at 760 mmHg
Melting Point 76 °C
Molecular Formula C9H10O3
Molecular Weight 166.174
Flash Point 119.0±15.3 °C
Exact Mass 166.062988
PSA 46.53000
LogP 1.72
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.574
Water Solubility slightly soluble
Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
CU6125000
CHEMICAL NAME :
Benzaldehyde, 3-ethoxy-4-hydroxy-
CAS REGISTRY NUMBER :
121-32-4
BEILSTEIN REFERENCE NO. :
1073761
LAST UPDATED :
199710
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C9-H10-O3
MOLECULAR WEIGHT :
166.19
WISWESSER LINE NOTATION :
VHR DQ CO2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1590 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>7940 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4480 mg/kg/70D-I
TOXIC EFFECTS :
Cardiac - other changes Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
250 mg/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4743 No. of Facilities: 26 (estimated) No. of Industries: 2 No. of Occupations: 17 No. of Employees: 2343 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4743 No. of Facilities: 2917 (estimated) No. of Industries: 20 No. of Occupations: 42 No. of Employees: 53949 (estimated) No. of Female Employees: 31080 (estimated)
Safety
Symbol GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS CU6125000
Packaging Group I; II; III
HS Code 2912420000
Preparation

N/A

FAQ

1.What is Ethyl Vanillin?

Ethyl vanillin, also known as ethyl vanillin, is a white to slightly yellow scale crystalline powder, sweet chocolate aroma and vanillin unique aroma, basically non-toxic, widely used in spices, cosmetics, food additives, medicine and other industries towel. The first flavor synthesized by mankind is vanillin, which was successfully synthesized by Dr. M. Hallman and Dr. G. Thiemann of Germany in 1874. In the food industry, the use of the same field and vanillin, especially for milk-based food fragrance, can be used alone or with vanillin, glycerin, etc. with the use. It can be used alone or in combination with vanillin, glycerin, etc. It is mainly used as a flavor enhancer for cosmetics in the cosmetic industry.

2.How is Ethyl Vanillin produced?

In a three-necked flask equipped with a dropping funnel, a reflux condenser tube and an electric stirrer, add o-ethoxyphenol, ethanol, sodium hydroxide, tertiary amine catalyst, control the temperature, add a calculated amount of chloroform drop by drop, control the rate of acceleration of the drop, drop by drop, and continue the reaction. After cooling, sulfuric acid was added to pH 2~3, filtered, sodium sulfate was removed, the residue was washed with anhydrous ethanol, and the filtrate was distilled under hydrodistillation until the skimmed liquid was free of oil beads. The remaining mixture was cooled, with red insoluble material at the bottom of the bottle, extracted with ether, the extracts were combined and dried with anhydrous sodium sulfate. Evaporate the ether, dissolve the residue in hot water, the aqueous layer of ethyl vanillin layer, the lower layer of impurities layer, while the heat is divided into liquids, the aqueous solution is concentrated under reduced pressure, cooling, crystallization, filtration, drying, to get the product.

3.How is Ethyl Vanillin stored and distributed?

Store under dry inert gas, keep container tightly closed, store in a cool, dry place Packed in galvanized iron drums. Store in a cool, ventilated place. The storage should be dedicated and not mixed with other items. Pay attention to fire prevention. Polymerization inhibitor should be added before storage and transportation. Before transportation, check whether the packing container is complete and sealed, and make sure the container is not leaking, collapsing, falling or damaged during transportation. Strictly prohibit mixing and transporting with oxidizing agents, acids, alkalis, edible chemicals and so on. The transport vehicle and ship must be thoroughly cleaned and sterilized, otherwise it is not allowed to ship other items. When transported by ship, the fitting position should be far away from bedrooms, kitchens, and isolated from the cabin, power supply, fire source and other parts. Road transportation should follow the prescribed route.

4.What is Ethyl Vanillin used for?

Usage: This product is a broad-spectrum spice, is one of the most important synthetic spices in the world, is an indispensable and important raw material in the food additives industry, its aroma is 3-4 times that of vanillin, with a strong aroma of vanilla beans, and long-lasting fragrance. It is widely used in food, chocolate, ice-cream, beverage and daily use cosmetics to enhance and fix the aroma. In addition, ethyl vanillin can be used as additives for feed, brightening agent in electroplating industry and intermediates in pharmaceutical industry. Package: It is packed in cardboard drums lined with polyethylene bags, net weight 25kg per drum, and in lkg plastic drums packed in dry cartons, net weight 10kg per carton.

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