Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
LW8400000
CHEMICAL NAME :
Gallic acid,
propyl ester
CAS REGISTRY NUMBER :
121-79-9
LAST UPDATED :
199710
DATA ITEMS
CITED :
27
MOLECULAR FORMULA :
C10-H12-O5
MOLECULAR WEIGHT
:
212.22
WISWESSER LINE NOTATION :
QR BQ CQ EVO3
HEALTH HAZARD DATA
ACUTE
TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
380
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2750 mg/kg
TOXIC EFFECTS :
Details
of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- hamster
DOSE/DURATION :
2480 mg/kg
TOXIC EFFECTS :
Details of toxic effects
not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
42 gm/kg/14D-C
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
700 mg/kg/7D-I
TOXIC EFFECTS :
Liver - other
changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
113750
mg/kg/13W-C
TOXIC EFFECTS :
Gastrointestinal - other changes
TYPE OF TEST :
TDLo
- Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- mouse
DOSE/DURATION :
84 gm/kg/14D-C
TOXIC EFFECTS :
Related to Chronic Data -
death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
168
gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
45 gm/kg
SEX/DURATION
:
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific
Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
19 gm/kg
SEX/DURATION
:
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on
Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500
mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed
implants per total number of implants)
TYPE OF TEST :
Micronucleus test
MUTATION
DATA
TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster
Ovary
DOSE/DURATION :
5 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for
the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of
the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY
10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),23,1985 *** NIOSH
STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82907 No. of
Facilities: 1188 (estimated) No. of Industries: 6 No. of Occupations: 8 No. of Employees:
5592 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code -
82907 No. of Facilities: 1806 (estimated) No. of Industries: 18 No. of Occupations: 29 No.
of Employees: 42475 (estimated) No. of Female Employees: 23494 (estimated)
