Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
GO7875000
CHEMICAL NAME :
p-Cresol,
2,6-di-tert-butyl-
CAS REGISTRY NUMBER :
128-37-0
LAST UPDATED :
199712
DATA
ITEMS CITED :
79
MOLECULAR FORMULA :
C15-H24-O
MOLECULAR WEIGHT
:
220.39
WISWESSER LINE NOTATION :
1X1&1&R BQ E1 CX1&1&1
HEALTH HAZARD
DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE
:
Administration onto the skin
SPECIES OBSERVED :
Human
TYPE OF TEST
:
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES
OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE
:
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Human - woman
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Gastrointestinal - gastritis Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50
- Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
890 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose,
50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Lungs,
Thorax, or Respiration - chronic pulmonary edema
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
138 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration -
chronic pulmonary edema Lungs, Thorax, or Respiration - other changes Blood -
hemorrhage
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180
mg/kg
TOXIC EFFECTS :
Behavioral - sleep
TYPE OF TEST :
LDLo - Lowest published
lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal -
cat
DOSE/DURATION :
940 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility,
diarrhea Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
TYPE
OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2100 mg/kg
TOXIC EFFECTS
:
Gastrointestinal - hypermotility, diarrhea Behavioral - tremor Lungs, Thorax, or
Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea
pig
DOSE/DURATION :
10700 mg/kg
TOXIC EFFECTS :
Gastrointestinal -
hypermotility, diarrhea Behavioral - tremor Lungs, Thorax, or Respiration - respiratory
depression
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
109
gm/kg/2Y-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin,
cholesterol) Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC)
count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
27
gm/kg/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - evidence of
thyroid hyperfunction Endocrine - changes in thyroid weight
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
37800 mg/kg/6W-C
TOXIC EFFECTS :
Liver - changes in liver
weight Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss
or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5600
mg/kg/16W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder -
other changes in urine composition
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
275 mg/kg/26W-C
TOXIC EFFECTS :
Liver - changes in liver weight Skin and
Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight
gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
112
gm/kg/80W-C
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical - Enzyme
inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed
oxidase (dealkylation, hydroxylation, etc.) Biochemical - Metabolism (Intermediary) - other
proteins
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5040
mg/kg/7D-C
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in
erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or
tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
13500 mg/kg/18D-I
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical -
Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
48600 mg/kg/30D-C
TOXIC EFFECTS
:
Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular
necrosis)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION
:
5 gm/kg/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung
weight Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate -
monkey
DOSE/DURATION :
14 gm/kg/4W-I
TOXIC EFFECTS :
Biochemical - Enzyme
inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - hamster
DOSE/DURATION :
1596 mg/kg/14D-C
TOXIC EFFECTS :
Liver -
changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight
gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other
transferases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
134
gm/kg/32W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney,
Ureter, Bladder - tumors Tumorigenic - cells (cultured) transformed
TYPE OF TEST
:
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
435 mg/kg/69W-C
TOXIC EFFECTS :
Tumorigenic
- Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal -
tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
247
gm/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Reproductive -
Tumorigenic effects - transplacental tumorigenesis Liver - tumors
TYPE OF TEST :
TD -
Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
247 gm/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic -
neoplastic by RTECS criteria Reproductive - Tumorigenic effects - ovarian tumors
TYPE OF
TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
1423 mg/kg/43W-C
TOXIC EFFECTS
:
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD -
Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
247 gm/kg
TOXIC EFFECTS :
Tumorigenic -
Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other
than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
963 gm/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by
RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
male 13
week(s) pre-mating female 13 week(s) pre-mating - 3 week(s) post-birth
TOXIC EFFECTS
:
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
18 gm/kg
SEX/DURATION :
male 2 week(s) pre-mating female 2
week(s) pre-mating - 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on
Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn -
behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
9 gm/kg
SEX/DURATION :
male 2 week(s) pre-mating female 2
week(s) pre-mating - 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on
Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE
OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE
:
35 gm/kg
SEX/DURATION :
male 10 week(s) pre-mating
TOXIC EFFECTS
:
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of
implants per female; total number of implants per corpora lutea)
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
43800
mg/kg
SEX/DURATION :
female 52 day(s) pre-mating female 1-21 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive
- Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at
day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
12600 mg/kg
SEX/DURATION :
female 1-21 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE
:
1200 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF
TEST :
DNA damage
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST
:
Unscheduled DNA synthesis
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST
:
Mutation test systems - not otherwise specified
TYPE OF TEST :
DNA
inhibition
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST :
Sperm
Morphology
MUTATION DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM
:
Rodent - hamster Ovary
REFERENCE :
MUREAV Mutation Research. (Elsevier Science
Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:
345,73,1995 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The
Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit
Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference
of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the
Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,161,1986 IARC Cancer
Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk
of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1-
1972- Volume(issue)/page/year: 40,161,1986 IARC Cancer Review:Group 3 IMSUDL IARC
Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW FEPRA7 Federation
Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD)
V.1-46, 1942-87. Volume(issue)/page/year: 35,89,1976 *** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993 OEL-BELGIUM:TWA 10 mg/m3 JAN 1993 OEL-FINLAND:TWA 10
mg/m3;STEL 20 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 10 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA
10 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 10 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3 JAN
1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE,
VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH
RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2,6-DI-t-BUTYL-p-CRESOL-air:10H TWA 10 mg/m3
REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS
#92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard
Survey (1974) NOHS Hazard Code - 83383 No. of Facilities: 1526 (estimated) No. of
Industries: 32 No. of Occupations: 39 No. of Employees: 28860 (estimated) NOES - National
Occupational Exposure Survey (1983) NOES Hazard Code - 83383 No. of Facilities: 27242
(estimated) No. of Industries: 210 No. of Occupations: 154 No. of Employees: 591238
(estimated) No. of Female Employees: 163774 (estimated)
