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L-Valine
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Basic
Common Name L-Valine
CAS Number 72-18-4
Molecular Weight 117.146
Density 1.1±0.1 g/cm3
Boiling Point 213.6±23.0 °C at 760 mmHg
Molecular Formula C5H11NO2
Melting Point 315ºC
MSDS Chinese USA
Flash Point 83.0±22.6 °C
Physical Chemistry
Density 1.1±0.1 g/cm3
Boiling Point 213.6±23.0 °C at 760 mmHg
Melting Point 315ºC
Molecular Formula C5H11NO2
Molecular Weight 117.146
Flash Point 83.0±22.6 °C
Exact Mass 117.078979
PSA 63.32000
LogP 0.20
Vapour Pressure 0.1±0.9 mmHg at 25°C
Index of Refraction 1.461
Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
YV9361000
CHEMICAL NAME :
Valine, L-
CAS REGISTRY NUMBER :
72-18-4
LAST UPDATED :
199706
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C5-H11-N-O2
MOLECULAR WEIGHT :
117.17
WISWESSER LINE NOTATION :
QVYZY1&1 -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5390 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
MUTATION DATA
TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81870 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 882 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81870 No. of Facilities: 811 (estimated) No. of Industries: 4 No. of Occupations: 16 No. of Employees: 19343 (estimated) No. of Female Employees: 14342 (estimated)
Safety
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn: Harmful;
Risk Phrases R40
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS YV9361000
HS Code 29224995
Preparation

N/A

FAQ

1.What is L-Valine?

L-Valine is an essential amino acid that plays a crucial role in maintaining overall health and well-being. Amino acids are the building blocks of proteins, and L-Valine is one of the 20 amino acids that are required for protein synthesis in the human body. It is classified as a branched-chain amino acid (BCAA) due to its unique molecular structure. L-Valine is an isomer, which means it has the same molecular formula as another amino acid, D-Valine, but a different arrangement of atoms in space. The L-Valine isomer is the biologically active form that is utilized by the body.

2.What are the benefits of valine?

Athletes and bodybuilders are best known for supplementing with this amino acid due to its ability to prevent muscle breakdown and boost athletic performance. How does it accomplish this? It helps supply the muscles with extra glucose for energy production during intense exercise. Studies using both human subjects and animal subjects support this benefit. A clinical study published in 2017 finds that acute supplementation of BCAAs (0.087 g/kg) increased the rate of recovery in isometric strength and perceived muscle soreness compared to placebo after a hypertrophy-based training session among diet-controlled, resistance-trained athletes. Another research study published in 2018 in the scientific journal Bioscience, Biotechnology, and Biochemistry specifically looked at the effects of valine on animal subjects during exercise. The results of the study demonstrate that acute supplementation of valine, but not leucine or isoleucine (the other BCAAs), is “effective for maintaining liver glycogen and blood glucose and increasing spontaneous activity after exercise, which could contribute to the reduction of fatigue during exercise.” Supplementation with branch-chain amino acids has been used for the following with some success as well: 1.Cirrhosis of the liver 2.Phenylketonuria 3.Athletic performance and mental decline during exercise at extreme temperature 4.Athletic performance and post-exercise infection at extreme temperature 5.Tardive dyskinesia

3.What foods are high in valine?

Dairy products, especially cottage cheese and yogurt;Eggs;Red meat like lamb and beef;Fish, including wild-caught salmon and trout;Fermented soy products, like natto and tempeh;Turkey and chicken;Seeds, including sunflower seeds, sesame seeds, flaxseeds and chia seeds;Nuts, like pistachios, cashews and almonds ;Beans, including navy beans, kidney beans, adzuki beans, chickpeas and lentils;Mushrooms;Gluten-free whole grains, like quinoa and brown rice L-valine supplements are commonly taken by weightlifters and performance athletes as part of their workout routines. People that are looking to increase their valine intake through supplements have a few options. One option is to take L-valine by itself. You can also take BCAA supplements that provide a balance of the amino acids L-leucine, L- isoleucine and L-valine. Both whey protein and egg protein supplements also contain BCAAs.

4.What are properties of L-Valine: Amino Acid Characteristics and Functions?

L-Valine exhibits several important characteristics and functions that contribute to its role in maintaining optimal health. As an essential amino acid, L-Valine cannot be synthesized by the body and must be obtained through dietary sources or supplementation. It is primarily metabolized in the liver and skeletal muscles, where it is used for energy production and protein synthesis. L-Valine is also involved in the synthesis of other essential molecules, such as glucose and fatty acids. One of the key functions of L-Valine is its role in promoting muscle growth and repair. It is a crucial component of muscle proteins and is necessary for the maintenance of muscle tissue. L-Valine, along with the other two branched-chain amino acids (leucine and isoleucine), stimulates muscle protein synthesis and prevents muscle breakdown. This makes L-Valine particularly important for athletes and individuals engaged in intense physical activity, as it can aid in muscle recovery and enhance performance. In addition to its role in muscle health, L-Valine also plays a significant role in the central nervous system. It acts as a precursor for the synthesis of neurotransmitters, such as gamma-aminobutyric acid (GABA), which is involved in regulating brain activity and promoting relaxation. L-Valine may also have a positive impact on mood and cognitive function. Research suggests that L-Valine supplementation may help improve memory, focus, and overall mental well-being.

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