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L-Aspartic acid
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Basic
Common Name L-Aspartic acid
CAS Number 56-84-8
Molecular Weight 133.103
Density 1.5±0.1 g/cm3
Boiling Point 264.1±30.0 °C at 760 mmHg
Molecular Formula C4H7NO4
Melting Point >300 °C (dec.)(lit.)
MSDS Chinese USA
Flash Point 113.5±24.6 °C
Physical Chemistry
Density 1.5±0.1 g/cm3
Boiling Point 264.1±30.0 °C at 760 mmHg
Melting Point >300 °C (dec.)(lit.)
Molecular Formula C4H7NO4
Molecular Weight 133.103
Flash Point 113.5±24.6 °C
Exact Mass 133.037506
PSA 100.62000
LogP -0.67
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.531
Water Solubility 5 g/L (25 ºC)
Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
CI9098500
CHEMICAL NAME :
Aspartic acid, L-
CAS REGISTRY NUMBER :
56-84-8
BEILSTEIN REFERENCE NO. :
1723530
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C4-H7-N-O4
MOLECULAR WEIGHT :
133.12
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25079 mg/kg/7D-C
TOXIC EFFECTS :
Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport
MUTATION DATA
TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81861 No. of Facilities: 803 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 5939 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81861 No. of Facilities: 634 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 9033 (estimated) No. of Female Employees: 6545 (estimated)
Safety
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;Xn: Harmful;
Risk Phrases R36
Safety Phrases S26-S24/25-S22
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS CI9098500
HS Code 29224995
Preparation

N/A

FAQ

1.What is L-Aspartic Acid?

Aspartic acid, otherwise known as L-aspartate, is basically a non-essential amino acid. It is mainly used to help improve metabolism. There are two forms of aspartic acid — L-aspartic acid and D-aspartic acid. L-aspartic acid vs. D-aspartic acid is a common topic. While the latter has a limited biological function, the former is directly merged into the proteins. L-aspartic acid is found in a variety of sources, such as fish, chicken, peanuts and lentils . Regarding its benefits, it is usually used to increase the strength of the muscles, improve sports performance and reduce fatigue. Aspartic acid is highly involved in the Krebs cycle or the citric acid cycle. It is within this cycle that other amino acids are created. This includes acids like arginine, lysine, asparagine, methionine and so on. Aspartic acid moves the NADH molecules to the mitochondria, where ATP is produced. The element thus produced controls cellular activity .

2.What are Food sources of L-Aspartic Acid?

Since L-aspartic acid is a non-essential amino acid, the human body is capable of producing it. However, in some cases, one might require additional supplements. This could be found either in natural food sources or in supplements. Those with eating disorders are likely to require more aspartic acid to combat the deficiency symptoms, such as depression or tiredness (x). Vegetable sources: L-aspartic acid in foods include oats, asparagus, sprouting seeds, avocado, sugar cane, almonds, peanuts, flax seeds, chicken, eggs, milk, lentils, fish and soy bean. Animal sources: Sausage meat, oysters, luncheon meats, wild game. Dietary supplements or salts like magnesium aspartate also contain this amino acid. Likewise, it is also present in sweeteners.

3.Whta are Side Effects of L-Aspartic Acid ?

Adverse Cholesterol Impact Changes in the levels of aspartic acid could lead to unwelcome changes in cholesterol. Since the liver and the kidneys regulate cholesterol, it is possible that the negative effects of aspartic acid on these organs could be responsible for changes in levels of cholesterol. Since our body’s organs work together seamlessly to offer the best health, when one organ doesn’t work properly, it could impact others as well . Bloating and Discomfort Higher intake of L-aspartic acid could lead to bloating, stomach problems, vomiting and so on. It could also cause loss of coordination and result in fatigue and tiredness . Diarrhea L-aspartic acid is available in a variety of commonly available foods. The branched-chain amino acid is used by athletes and sportspersons to improve their performance, reduce fatigue and so on. However, overconsumption could lead to diarrhea and other forms of digestion troubles . Elevated Liver Enzymes Another side effect of consuming L-aspartic acid is the abnormally elevated liver enzymes. Aspartate transaminase and alanine transaminase are liver proteins that are extremely critical for proper liver functioning. Increased levels highlight damage to liver cells or inflammation. In conclusion, it is suggested that taking aspartic acid could affect liver function in a negative manner .

4.What are the benefits of L-Aspartic Acid?

Energy and Glucose Production Aspartic acid is extremely important and plays a critical role in generating cellular activity. It is responsible to transport NADH molecules to the mitochondria, which is later used to produce ATP. This coenzyme enables metabolism and supports other cellular activity. With this, we can understand that the higher the NADH in the cell, the higher the ATP that can be produced. Since this leads to better and improved metabolism, it also coverts as increased energy for our body . Memory and Cognition L-aspartic acid is significant for cognitive function since it is responsible for transporting NADH to the brain. This element helps the brain in maintaining the correct levels of particular chemicals and some neurotransmitters that are critical for effective mental functioning. Immune Function Aspartic acid is a critical factor regarding the production of antibodies and immunoglobulins. These glycoprotein molecules are created by the plasma cells or the white blood cells. The antibodies work to identify and bind to bacteria, viruses or other antigens. They are also responsible for destroying foreign bodies and other elements. Since there are plenty of different immunoglobulin isotypes, our body would not be able to manufacturer these compounds with L-aspartic amino acid . Removal of Toxins The body produces toxins as a consequence of cellular activity. L-aspartic acid works to remove ammonia and other toxins. This is because, if the ammonia levels cannot be maintained, it could potentially damage or harm the brain, the liver and the central nervous system .

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