Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
CF1995500
CHEMICAL NAME :
Arginine,
monohydrochloride, L-
CAS REGISTRY NUMBER :
1119-34-2
LAST UPDATED
:
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA
:
C6-H14-N4-O2.Cl-H
MOLECULAR WEIGHT :
210.70
WISWESSER LINE NOTATION
:
MUYZM3YZVQ &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- rat
DOSE/DURATION :
12 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time
(including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration -
dyspnea
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American
Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 62,49,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
3793 mg/kg
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax,
or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature
decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press,
Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 58,253,1955 **
REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF
EXPOSURE :
Intraperitoneal
DOSE :
90 mg/kg
SEX/DURATION :
female 1-6 day(s)
after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities -
musculoskeletal system
REFERENCE :
AJEBAK Australian Journal of Experimental Biology
and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year:
51,553,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL
EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code -
81859 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of
Employees: 857 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard
Code - 81859 No. of Facilities: 585 (estimated) No. of Industries: 3 No. of Occupations: 13
No. of Employees: 5477 (estimated) No. of Female Employees: 2954 (estimated)
