Common Name	Glycine
CAS Number	56-40-6
Molecular Weight	75.067
Density	1.3±0.1 g/cm3
Boiling Point	240.9±23.0 °C at 760 mmHg
Molecular Formula	C2H5NO2
Melting Point	240 °C (dec.)(lit.)
MSDS	Chinese USA
Flash Point	99.5±22.6 °C

Density	1.3±0.1 g/cm3
Boiling Point	240.9±23.0 °C at 760 mmHg
Melting Point	240 °C (dec.)(lit.)
Molecular Formula	C2H5NO2
Molecular Weight	75.067
Flash Point	99.5±22.6 °C
Exact Mass	75.032028
PSA	63.32000
LogP	-1.03
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.461
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	25 g/100 mL (25 ºC)

CHEMICAL IDENTIFICATION
RTECS NUMBER :
MB7600000
CHEMICAL NAME :
Glycine
CAS REGISTRY NUMBER :
56-40-6
LAST UPDATED :
199710
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C2-H5-N-O2
MOLECULAR WEIGHT :
75.08
WISWESSER LINE NOTATION :
Z1VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7930 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4920 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle weakness Behavioral - ataxia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
45 gm/kg/30D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count
MUTATION DATA
TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,279,1992 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80389 No. of Facilities: 1797 (estimated) No. of Industries: 17 No. of Occupations: 25 No. of Employees: 25710 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80389 No. of Facilities: 3706 (estimated) No. of Industries: 24 No. of Occupations: 48 No. of Employees: 115042 (estimated) No. of Female Employees: 83784 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R33
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	MB7600000
HS Code	29224910

N/A

1.What is glycine?

Glycine is an amino acid with a number of important functions in the body. Glycine acts as a neurotransmitter, a component of collagen, and as a precursor to various biomolecules (e.g., creatine, heme), among other roles. Glycine is often considered conditionally essential, meaning it can usually be produced in the body in sufficient amounts. However, in certain contexts (e.g., pregnancy) more glycine may be needed from the diet. Glycine is found in most protein sources, meaning common sources of glycine include meat, eggs, soybeans, lentils, and dairy products.

2.What are glycine’s main benefits?

A few studies have found supplementation with glycine can improve sleep quality, with subsequent benefits to cognitive function. High doses of glycine have been shown to improve symptoms of schizophrenia. Glycine may reduce the blood glucose response to carbohydrate ingestion. Glycine is a major component of collagen (around 25% by weight) and for this reasons is often taken to improve joint health, but human evidence in this area is currently lacking.

3.What are glycine’s main drawbacks?

In high amounts, glycine supplementation can cause gastrointestinal symptoms, including nausea and abdominal pain.

4.How does glycine work?

Glycine supplementation likely works through different mechanisms depending on the outcome of interest. Glycine is a co-agonist of N-methyl-D-aspartate (NMDA) receptor, meaning glycine plays a role in activating this receptor in the brain. Glycine’s effect on the NMDA receptor has been proposed as underlying the improvements in both sleep and symptoms of schizophrenia with supplementation. Glycine may benefit sleep by lowering core body temperature, as a warm body temperature can adversely affect sleep quality.