Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
PD0456000
CHEMICAL NAME :
Methionine,
DL-
CAS REGISTRY NUMBER :
59-51-8
LAST UPDATED :
199706
DATA ITEMS CITED
:
14
MOLECULAR FORMULA :
C5-H11-N-O2-S
MOLECULAR WEIGHT :
149.23
WISWESSER
LINE NOTATION :
QV1YZ1S1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST
:
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo.
Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo
104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST :
LDLo -
Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo.
Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo
104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST :
LD - Lethal
dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
>400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo.
Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo
104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST :
LDLo -
Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent
- mouse
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo.
Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo
104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST :
LDLo -
Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo.
Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo
104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977
TYPE OF TEST :
LDLo -
Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo.
Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo
104, Japan) V.1- 1972- Volume(issue)/page/year: 5,2041,1977 ** OTHER MULTIPLE DOSE TOXICITY
DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
36
gm/kg/30D-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood -
changes in leukocyte (WBC) count
REFERENCE :
JONUAI Journal of Nutrition.
(Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928-
Volume(issue)/page/year: 79,101,1963
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
21 gm/kg/13D-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter,
Bladder - changes in bladder weight
REFERENCE :
JONUAI Journal of Nutrition.
(Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928-
Volume(issue)/page/year: 106,1714,1976
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
39 gm/kg/20D-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter,
Bladder - changes in bladder weight Endocrine - changes in spleen weight
REFERENCE
:
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD
20014) V.1- 1928- Volume(issue)/page/year: 106,1714,1976
TYPE OF TEST :
TDLo - Lowest
published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird -
turkey
DOSE/DURATION :
33600 mg/kg/4W-C
TOXIC EFFECTS :
Nutritional and Gross
Metabolic - weight loss or decreased weight gain
REFERENCE :
POSCAL Poultry Science.
(Poultry Science Assoc., Inc., 309 W. Clark St., Champaign, IL 61820) V.1- 1921-
Volume(issue)/page/year: 57,699,1978 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
40
gm/kg
SEX/DURATION :
female 1-20 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Fertility - other measures of fertility Reproductive - Effects on Embryo
or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive -
Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE
:
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 33,109,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY
DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3271 No. of
Facilities: 1272 (estimated) No. of Industries: 5 No. of Occupations: 27 No. of Employees:
16781 (estimated) No. of Female Employees: 4397 (estimated)
