Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
VZ4050000
CAS REGISTRY NUMBER
:
497-19-8
LAST UPDATED :
199710
DATA ITEMS CITED :
20
MOLECULAR FORMULA
:
C-O3.2Na
MOLECULAR WEIGHT :
105.99
WISWESSER LINE NOTATION :
QVQ &-NA-
2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize
test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent
- rabbit
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A
Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,7,1972
TYPE OF TEST :
Standard
Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED
:
Rodent - rabbit
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni
Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,8,1972
TYPE OF TEST
:
Rinsed with water
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES
OBSERVED :
Rodent - rabbit
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub.
Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year:
23,281,1982
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE
:
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE
:
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational
Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher
information, see MTPEEI Volume(issue)/page/year: 20(11),55,1976 ** ACUTE TOXICITY DATA
**
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4090 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE
:
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V.,
Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
Volume(issue)/page/year: -,8,1972
TYPE OF TEST :
LC50 - Lethal concentration, 50
percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
2300 mg/m3/2H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration
- dyspnea Gastrointestinal - other changes
REFERENCE :
ENVRAL Environmental Research.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year:
31,138,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6600 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE
:
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational
Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher
information, see MTPEEI Volume(issue)/page/year: 20(11),55,1976
TYPE OF TEST :
LC50 -
Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES
OBSERVED :
Rodent - mouse
DOSE/DURATION :
1200 mg/m3/2H
TOXIC EFFECTS
:
Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - other changes
REFERENCE
:
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1967- Volume(issue)/page/year: 31,138,1983
TYPE OF TEST :
LD50 - Lethal dose, 50
percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
117 mg/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires
des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher
information, see CRASEV. Volume(issue)/page/year: 257,791,1963
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
2210 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian
Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33,
Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year:
33,266,1970
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF
EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION
:
800 mg/m3/2H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - other changes
REFERENCE :
ENVRAL Environmental Research. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year:
31,138,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest
published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED
:
Mammal - species unspecified
DOSE/DURATION :
16200 ug/m3/17W-I
TOXIC EFFECTS
:
Sense Organs and Special Senses (Olfaction) - change in sensation of smell Vascular -
BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration -
respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye
Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(11),55,1976 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo -
Lowest published toxic dose
ROUTE OF EXPOSURE :
Intrauterine
DOSE :
84800
ng/kg
SEX/DURATION :
female 4 day(s) after conception
TOXIC EFFECTS
:
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of
implants per female; total number of implants per corpora lutea)
REFERENCE :
JRPFA4
Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way,
Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 63,365,1981 *** U.S.
STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR
RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH
STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 68850 No. of
Facilities: 148455 (estimated) No. of Industries: 389 No. of Occupations: 193 No. of
Employees: 1143671 (estimated) NOES - National Occupational Exposure Survey (1983) NOES
Hazard Code - 68850 No. of Facilities: 97764 (estimated) No. of Industries: 385 No. of
Occupations: 220 No. of Employees: 2001842 (estimated) No. of Female Employees: 761463
(estimated)
