Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
GE7350000
CHEMICAL NAME :
Citric
acid
CAS REGISTRY NUMBER :
77-92-9
BEILSTEIN REFERENCE NO. :
0782061
LAST
UPDATED :
199710
DATA ITEMS CITED :
18
MOLECULAR FORMULA
:
C6-H8-O7
MOLECULAR WEIGHT :
192.14
WISWESSER LINE NOTATION
:
QV1XQVQ1VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard
Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED
:
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke
Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,658,1986
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE
:
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE
:
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague,
Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,658,1986 ** ACUTE TOXICITY DATA
**
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE
:
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91,
Japan) V.1- 1967- Volume(issue)/page/year: 43,561,1992
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
290 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
TOVEFN
Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
Volume(issue)/page/year: (5),9,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
5500 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration -
other changes Musculoskeletal - other changes
REFERENCE :
TAKHAA Takeda Kenkyusho Ho.
Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85
Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year:
30,25,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5040 mg/kg
TOXIC
EFFECTS :
Lungs, Thorax, or Respiration - other changes Musculoskeletal - other
changes
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research
Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
Japan) V.29- 1970- Volume(issue)/page/year: 30,25,1971
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED
:
Rodent - mouse
DOSE/DURATION :
903 mg/kg
TOXIC EFFECTS :
Details of toxic
effects not reported other than lethal dose value
REFERENCE :
TXCYAC Toxicology.
(Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
Volume(issue)/page/year: 62,203,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent -
mouse
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration -
other changes Musculoskeletal - other changes
REFERENCE :
TAKHAA Takeda Kenkyusho Ho.
Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85
Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year:
30,25,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of
salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental
Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1-
1909/10- Volume(issue)/page/year: 94,65,1948
TYPE OF TEST :
LDLo - Lowest published
lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral -
convulsions or effect on seizure threshold Behavioral - muscle contraction or
spasticity
REFERENCE :
IECHAD Industrial and Engineering Chemistry. (Washington, DC)
V.15-62, 1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year:
15,628,1923
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
330
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs,
Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of
salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental
Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1-
1909/10- Volume(issue)/page/year: 94,65,1948 *** U.S. STANDARDS AND REGULATIONS *** EPA
FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register.
(U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA
*** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey
(1974) NOHS Hazard Code - 19680 No. of Facilities: 28313 (estimated) No. of Industries: 157
No. of Occupations: 112 No. of Employees: 307205 (estimated) NOES - National Occupational
Exposure Survey (1983) NOES Hazard Code - X1191 No. of Facilities: 22 (estimated) No. of
Industries: 1 No. of Occupations: 2 No. of Employees: 130 (estimated) No. of Female
Employees: 108 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard
Code - 19680 No. of Facilities: 49113 (estimated) No. of Industries: 244 No. of Occupations:
182 No. of Employees: 1691218 (estimated) No. of Female Employees: 1083005 (estimated)
