Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
AU8400000
CHEMICAL NAME :
Adipic
acid
CAS REGISTRY NUMBER :
124-04-9
BEILSTEIN REFERENCE NO. :
1209788
LAST
UPDATED :
199712
DATA ITEMS CITED :
13
MOLECULAR FORMULA
:
C6-H10-O4
MOLECULAR WEIGHT :
146.16
WISWESSER LINE NOTATION
:
QV4VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize
test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent -
rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold,
J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,315,1986 ** ACUTE
TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF
EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>11
gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
(V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year:
48(9),72,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
275
mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - other changes Blood - hemorrhage
REFERENCE :
JAFCAU Journal of
Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB
57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year:
5,759,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1900 mg/kg
TOXIC
EFFECTS :
Gastrointestinal - other changes
REFERENCE :
JAFCAU Journal of
Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB
57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year:
5,759,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
680
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Blood -
hemorrhage
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American
Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 5,759,1957
TYPE OF TEST :
LD50 - Lethal
dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rabbit
DOSE/DURATION :
>11 gm/kg
TOXIC EFFECTS :
Details of toxic effects not
reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For
English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 48(9),72,1983 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 DTLVS* The
Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 4
mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL
EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code -
84427 No. of Facilities: 1068 (estimated) No. of Industries: 21 No. of Occupations: 42 No.
of Employees: 14846 (estimated) NOES - National Occupational Exposure Survey (1983) NOES
Hazard Code - 84427 No. of Facilities: 6259 (estimated) No. of Industries: 54 No. of
Occupations: 66 No. of Employees: 140635 (estimated) No. of Female Employees: 77996
(estimated)
