Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
AF1225000
CHEMICAL NAME :
Acetic
acid
CAS REGISTRY NUMBER :
64-19-7
BEILSTEIN REFERENCE NO. :
0506007
LAST
UPDATED :
199806
DATA ITEMS CITED :
69
MOLECULAR FORMULA
:
C2-H4-O2
MOLECULAR WEIGHT :
60.06
WISWESSER LINE NOTATION :
QV1
HEALTH
HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
Standard Draize test
ROUTE OF
EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
TYPE OF TEST
:
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES
OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE
:
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST
:
Rinsed with water
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES
OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION
:
1470 ug/kg
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of
esophagus Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal -
ulceration or bleeding from large intestine
TYPE OF TEST :
TCLo - Lowest published
toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED
:
Human
DOSE/DURATION :
816 ppm/3M
TOXIC EFFECTS :
Sense Organs and Special
Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) -
effect, not otherwise specified Lungs, Thorax, or Respiration - other changes
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Rectal
SPECIES
OBSERVED :
Human - child
DOSE/DURATION :
281 uL/kg
TOXIC EFFECTS
:
Gastrointestinal - alteration in gastric secretion Liver - liver function tests
impaired Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute
tubular necrosis)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF
EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
308
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3310 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
:
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16000
ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
:
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5620
ppm/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Blood - other
changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
525
mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE
OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rabbit
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details
of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 -
Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the
skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1060 uL/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
600
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
:
Rectal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
600
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22680
mg/kg/9W-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross
Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest
published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED
:
Rodent - rat
DOSE/DURATION :
5070 ug/m3/24H/95D-C
TOXIC EFFECTS :
Kidney,
Ureter, Bladder - other changes in urine composition Blood - changes in leukocyte (WBC)
count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true
cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Oral
DOSE :
700 mg/kg
SEX/DURATION :
lactating female 18 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
Intratesticular
DOSE :
400 mg/kg
SEX/DURATION :
male 1 day(s)
pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. #
males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF
TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss
and nondisjunction
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST
:
Unscheduled DNA synthesis
TYPE OF TEST :
Mutation test systems - not otherwise
specified
MUTATION DATA
TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM
:
Rodent - hamster Ovary
REFERENCE :
MUREAV Mutation Research. (Elsevier Science
Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:
240,195,1990 *** REVIEWS *** ACGIH TLV-STEL 37 mg/m3 (15 ppm) DTLVS* The Threshold Limit
Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference
of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997 ACGIH TLV-TWA 25 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and
Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental
Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997
TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 21,28,1960 TOXICOLOGY REVIEW
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed.
Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 39,299,1978 *** U.S. STANDARDS AND
REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC
Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC
20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 10 ppm (25
mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs)
booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH),
Cincinnati, OH, 1996 Volume(issue)/page/year: 3,2,1971 OSHA PEL (Gen Indu):8H TWA 10 ppm (25
mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL
(Construc):8H TWA 10 ppm (25 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government
Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10 ppm (25 mg/m3) CFRGBR Code of Federal
Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 10 ppm (25 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE
LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (25 mg/m3);STEL 15 ppm (37 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 10 ppm (25 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (25 mg/m3);STEL 15 ppm (37
mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (25 mg/m3) JAN 1993 OEL-FINLAND:TWA 10 ppm (25
mg/m3);STEL 15 ppm (37 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 10 ppm (25 mg/m3) JAN 1993
OEL-GERMANY:TWA 10 ppm (25 mg/m3) JAN 1993 OEL-HUNGARY:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993
OEL-INDIA:TWA 10 ppm (25 mg/m3);STEL 15 ppm (37 mg/m3) JAN 1993 OEL-JAPAN:TWA 10 ppm (25
mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (25 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA
10 ppm (25 mg/m3) JAN 1993 OEL-POLAND:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:TWA 10 ppm;STEL 5
mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 10 ppm (25 mg/m3);STEL 15 ppm (35 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 10 ppm (25 mg/m3);STEL 20 ppm (50 mg/m3) JAN 1993 OEL-THAILAND:TWA 10
ppm (25 mg/m3) JAN 1993 OEL-TURKEY:TWA 10 ppm (25 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10
ppm (25 mg/m3);STEL 15 ppm (35 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA
check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS
DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO
ACETIC ACID-air:10H TWA 10 ppm;STEL 15 ppm REFERENCE : NIOSH* National Institute for
Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and
Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY
DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 01568 No. of
Facilities: 51469 (estimated) No. of Industries: 264 No. of Occupations: 150 No. of
Employees: 486503 (estimated) NOES - National Occupational Exposure Survey (1983) NOES
Hazard Code - 01568 No. of Facilities: 49403 (estimated) No. of Industries: 266 No. of
Occupations: 169 No. of Employees: 907205 (estimated) No. of Female Employees: 322123
(estimated)
